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mRNA: The Future Beyond COVID Vaccines

Messenger RNA (mRNA) prophylactic vaccines have made major breakthroughs in 2020 and 2021 with both the Pfizer/BioNTech and Moderna COVID-19 vaccines gaining approval in more than 150 countries. These mRNA COVID vaccines have been developed much faster and with superior clinical profiles when compared to other more conventional modalities.

The success of mRNA vaccines against COVID-19 has driven a new wave of investment that could accelerate the exploration of mRNA application in other spaces. The market cap for mRNA publicly listed companies once reached ~$280bn in Sep 2021. Since 2008, the mRNA pipeline has grown significantly, almost tripling over the past two years.

This is just the start. Current mRNA therapies in development can be classified into three major applications based on their...

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