Several pharmaceutical companies, including Bayer, Eisai, Gilead, MSD, Novo Nordisk and Sanofi, have backed warnings from the Association of the British Pharmaceutical Industry that the £3.3bn “extreme revenue clawback” companies will have to pay the government in 2023 means they will invest less in the UK and launch fewer new products there.
UK Industry Calls For 'Early & Open' Talks Over ‘Extreme’ 2023 Clawbacks
The current UK approach to drug pricing and access is "broken," and early talks with the government next year will be necessary to set out a "completely new future settlement," the pharmaceutical industry has warned. By contrast, the government claims that the pricing scheme is working as intended.

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The weight management drug, Mysimba, continues to demonstrate a positive benefit-risk balance but the data available are not sufficient to fully determine the cardiovascular safety beyond 12 months. Meanwhile, Currax this month announced the publication of a peer-reviewed study of Mysimba that followed patients for over 4.7 years and found no evidence of excess cardiovascular risk.
Health technology assessment body NICE said it has taken on feedback about the implications of allowing higher cost-effectiveness thresholds for some medicines after senior health economists offered diverging views on its methods.
The European Medicines Agency has recommended five drugs for EU-wide approval , including Averoa’s Xoanacyl for concomitant hyperphosphatemia. Two companies have withdrawn their marketing authorization applications.
Eli Lilly’ will request a re-examination after the European Medicines Agency declined to recommend its Alzheimer’s disease drug Kisunla for EU approval.
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In his resignation letter, the CBER director said he was willing to work with HHS Secretary Robert F. Kennedy Jr. to address concerns about vaccine safety, but "it has become clear that truth and transparency are not desired by the secretary."
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The April departures of Paul Kluetz and Marc Theoret follow resignations by other senior agency scientific staff and come on top of HHS’ plans to lay off 3,500 FDA employees.