Different, But Not Poles Apart: Running Decentralized Clinical Trials In EU & US

This second segment of a two-part article on a regional comparison of EU and US approaches to decentralized clinical trials highlights the differences between the two regions relating to the more practical aspects of setting up and running such studies.

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EU & US regulators require clear communication between investigators and individuals delegated to preform trial-related tasks • Source: Shutterstock

EU and US regulators are closely aligned in their efforts to support modernization in clinical research and their recent recommendations on decentralized clinical trials (DCT) are a testament to this fact. There are, however, some differences between the two regulators when it comes to their advice on running DCTs.

EU regulators offered their harmonized perspective on the use of decentralized elements in clinical trials in a final recommendation paper in December 2022. The US Food and Drug Administration published its draft DCT guidance in May, with stakeholder comments due 1 August

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