Acorda's Parkinson's Drug Tozadenant May Not Survive Safety Setback

The safety problems reported for tozadenant – including deaths – have not been reported for other A2a receptor inhibitors and the company sees them as "idiosyncratic," stirring doubts about a commercial future.

MR  image of Human brain

Even if Acorda Therapeutics Inc.'s A2a receptor inhibitor tozadenant gets past the treatment-related deaths seen in Parkinson's disease trials and winds up getting approved, it still may struggle commercially.

Tozadenant is an adenosine 2a (A2a) receptor inhibitor acquired from Biotie Therapies Corp. in 2016. (Also see "Parkinson’s Niche To Expand With New Drugs, More Patients" - Scrip, 22 March, 2017.) Acorda announced Nov

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