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Can Lilly’s Cluster Headache Data Differentiate Its CGRP Inhibitor?

 
• By Joseph Haas

Galcanezumab was able to reduce episodic cluster headaches compared to placebo, but missed statistical significance for chronic cluster headaches. Amgen’s Aimovig still is first in line to reach the market in the anti-CGRP class.

nerve cells, concept for neurodegenerative and neurological disease

Lilly Research Laboratories's galcanezumab moved into the lead in the treatment of cluster headaches with a calcitonin gene-related peptide (CGRP) inhibitor via Phase III data reported May 15, but analysts wonder how much of an impact this will have in the ultra-competitive CGRP space.

The Indianapolis pharma said that galcanezumab hit the primary endpoint in a 106-patient, Phase III study in episodic cluster headaches, but it failed to show statistical significance in a larger...

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