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Teva's CGRP Inhibitor Fails In Chronic Cluster Headaches, Continues In Episodic

 
• By Mandy Jackson

Unlike the migraine space, there is only one competitor for Teva's CGRP inhibitor in cluster headaches, but that opportunity narrowed with fremanezumab's failure in chronic cluster headaches, though a trial in episodic cluster headaches is ongoing.

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Teva Pharmaceutical Industries Ltd.'s latest update on fremanezumab in cluster headaches will lessen the calcitonin gene-related peptide (CGRP) inhibitor's potential market by a few hundred thousand patients, but the biologic's main opportunity lies in the much larger migraine headache market.

Teva said on June 15 that it will discontinue a Phase III clinical trial testing fremanezumab in the prevention of chronic cluster headaches after a pre-specified futility analysis found that the CGRP inhibitor was unlikely to meet the primary endpoint of mean change from baseline in the monthly average number of headaches during a 12-week period

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