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Alexion Continues Pipeline Rebuilding With $400m Takeout Of Syntimmune

 
• By Joseph Haas

Alexion’s third deal this year brings privately held Syntimmune and its Phase Ib/IIa candidate for three IgG-mediated rare disorders, including warm autoimmune hemolytic anemia, for a $400m upfront price tag.

3-D Rendering Red Blood Cells

Alexion Pharmaceuticals Inc. could recreate the successful model for its blockbuster complement inhibitor Soliris with another pipeline-in-a-product opportunity, through its Sept. 26 acquisition of the privately held Syntimmune Inc. and its mid-stage immunoglobulin G (IgG)-targeting candidate being studied in three rare disorders, which moves Alexion into the burgeoning neonatal Fc receptor (FcRn) area.

For the past 12 months, since a 20% workforce reduction and its move from Connecticut to Boston, Alexion has been reworking its pipeline to reduce its dependency on Soliris (eculizumab), which yielded 88% of the biotech’s revenues in 2017. (Also see "Alexion Restructuring Deemed A Necessary Evil" - Scrip, 14 September, 2017

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