Atopic Dermatitis: Ruxolitinib And Baricitinib Spearheading New Therapies

Wave Of New Treatments Expected Over The Next Few Years.

Top-line Phase III results from Incyte’s TruE-AD2 study of ruxolitinib cream and Eli Lilly’s BREEZE-AD4 and BREEZE-AD5 studies of oral baricitinib show that the compounds achieved primary endpoints in atopic dermatitis, and they may eventually challenge Sanofi’s Dupixent’s growth in the sector.  

Dermatitis
Atopic dermatitis can be painful and unsightly. • Source: Shutterstock

Incyte Corp. is expecting clinical data later this quarter from a second pivotal study, TRuE-AD1, of its topical formulation of JAK inhibitor, ruxolitinib, in mild-to-moderate atopic dermatitis, and the company says it is committed to developing ruxolitinib cream as a first-line option for the condition.

The competitive pressure to become a contender in the atopic dermatitis market ticked up this week, with the US biotech announcing the bare bones of positive top-line clinical data from another

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