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Cara’s Korsuva Impresses Against Pruritus In Hemodialysis Patients

Pivotal KALM-2 Study Meets Primary Endpoint

 
• By John Davis

Cara Therapeutics and licensee Vifor Pharma have released positive topline data from the KALM-2 study in chronic kidney disease patients with moderate-to-severe pruritus undergoing hemodialysis, using a first-in-class selective kappa opioid receptor agonist which does not enter the CNS.  

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• Source: Shutterstock

Top-line results from KALM-2, the second of two Phase III studies of Cara Therapeutics Inc.'s pruritus therapy, Korsuva (CR845/difelikefalin), have confirmed the efficacy of the intravenous therapy to treat the condition in patients with chronic kidney disease on dialysis.

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