Horizon And Arrowhead To Develop RNAi Therapeutic For Gout

Target Is Xanthine Dehydrogenase, Primary Source Of Serum Uric Acid

22 Jun 2021

• By Sten Stovall

Arrowhead and Horizon Therapeutics have inked a deal to develop an investigational RNA interference therapy for uncontrolled gout, under which Arrowhead stands to get $40m upfront and up to $660m in milestones.

Gout Pact Will Give Arrowhead $40m upfront • Source: Alamy

Gout specialist Horizon Therapeutics plc has entered a world-wide development and licensing pact with Arrowhead Pharmaceuticals, Inc. under which the latter will develop the previously undisclosed discovery-stage investigational RNA interference (RNAi) therapeutic ARO-XDH as a potential treatment for people with uncontrolled gout.

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