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Chinese Biotechs Partner Up 18.2-Targeting ADCs Amid Intense Domestic Competition

 
• By Dexter Jie Yan

Following rapid R&D growth in the area, China now has roughly 40 drug candidates targeting Claudin 18.2 across various modalities including monoclonal antibodies, antibody-drug conjugates and bispecific antibodies, with a number of contenders now striking international licensing-out deals in a bid to get ahead of rivals.

More and more Chinese Biotechs are teaming up with larger-scale domestic pharma companies for wider market access.
Three deals for Claudin 18.2-targeting ADCs between China/US firms since May • Source: Alamy

Since May, Chinese biotechs have rushed to cut deals with US pharma companies for global rights to Claudin 18.2-targeting antibody-drug conjugate (ADC) assets amid cut-throat domestic competition in the field.

The latest partnerships have come from CSPC Megalith Biopharmaceutical under Hong Kong-listed CSPC Pharmaceutical Group Limited and Kelun-Biotech, a...

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China Signals Restarting IPOs For Unprofitable Biotechs

 
• By Dexter Jie Yan

The China Securities Regulatory Commission has proposed a new “growth tier” for the STAR Market of the Shanghai Stock Exchange, to reinstate the market’s listing standards for unprofitable firms.

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Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
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AstraZeneca Taps Into China’s R&D Engine With CSPC Alliance

 
• By Andrew McConaghie

After in-licensing a cardiovascular candidate last year, AstraZeneca has signed a strategic drug discovery alliance, which could generate billions of dollars in payments to the Chinese firm.

More from Focus On Asia

Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
• By Dexter Jie Yan

Henlius is investigating the optimum dose for its PD-L1-targeting antibody-drug conjugate HLX43 to support potential first-line use, its CEO explains to Scrip.

Big Top-Level Shifts At Sun: Ganorkar Is MD, Ex-Takeda Exec To Helm US Business

 
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Sun’s founder hands top job to company longtimer Kirti Ganorkar as the firm implements a “structured and forward-looking” succession plan, while Richard Ascroft will lead the Indian drugmaker’s North America business.

AstraZeneca Taps Into China’s R&D Engine With CSPC Alliance

 
• By Andrew McConaghie

After in-licensing a cardiovascular candidate last year, AstraZeneca has signed a strategic drug discovery alliance, which could generate billions of dollars in payments to the Chinese firm.