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Cassava’s Simufilam Continues To Alienate Investors Despite Some Phase II Alzheimer’s Promise

 
• By Ayisha Sharma

The US firm is touting top-line data from an open-label Alzheimer’s disease trial as a net positive, but the lack of p-values and a declining trend in efficacy left some investors and analysts lukewarm.  

Businessman walking on animated red arrow that is pointing diagonal and downwards
Simufilam's Efficacy Has Been Declining With Each Data Release • Source: Shutterstock

Cassava Sciences, Inc.’s simufilam has shown some signs of promise in a Phase II trial in Alzheimer’s disease (AD)but concerns about lack of detail on statistical significance as well as a general downward trend in responses have dampened its shine.

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