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Chinese ADC Developers Catch Up with Global Players In Advancing Key Payloads

Multiple Active Players

 
• By Dexter Jie Yan

Chinese pharma firms led by Kelun are moving fast to develop the next-generation of cytotoxic "warheads," a key component of antibody-drug conjugates, disclosed company executives at conference in Suzhou.

tweak the payloads
Chinese pharma companies are busy tweaking the payloads of their antibody-drug conjugates • Source: Shutterstock

Chinese drug makers are tweaking the tumor-killing payloads of their antibody-drug conjugate (ADC) candidates, as the key component of these emerging oncologic agents comes to the fore in the global race for potential best-in-class therapies.

While a number of cytotoxic candidates are up for grabs, ADC developers in China are primarily focused on the DNA topoisomerase I inhibitors (TOP1i) class, already well represented by the commercial success of

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