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EvolveImmune Targets Lymphoma With Novel T-Cell Engagers Harnessing CD2

 
• By Ayisha Sharma

Emerging Company Profile: The firm’s use of the CD2 co-stimulant in its T cell engager design could significantly boost anti-tumor efficacy while addressing T cell exhaustion, with a first-in-human trial planned for 2024.  

Emerging Company Profile: EvolveImmune Therapeutics
The EVOLVE Platform Is Designed To Address T-Cell Exhaustion • Source: Shutterstock

EvolveImmune Therapeutics, Inc. is leveraging its proprietary EVOLVE platform to develop three-pronged T cell engagers that could reduce immune evasion by tumor cells via CD2 activation, with an initial focus on treating lymphomas.

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Immusoft Goes For Cell Therapy Plan ‘B’

 
• By Alaric DeArment

Emerging Company Profile: CEO Sean Ainsworth spoke with Scrip about how the company is developing B-cell therapies to treat a range of diseases, starting with MPS I.

Sanofi-Backed Resalis Brings MicroRNA To Obesity

 
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Emerging Company Profile: Resalis will soon start human trials of an oligonucleotide targeting a microRNA that is overexpressed in obese mice, but much remains to be proven in humans.

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Emerging Company Profile: The Maryland-based biotech is working on a functional cure for type 1 diabetes that is similar to Vertex’s VX-880 – but with some key differences.

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