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Bladder Cancer Failure Is Another Setback For Gilead’s Trodelvy

 
• By Andrew McConaghie

A missed survival endpoint in the TROPiCS-04 confirmatory trial could spell end to Trodelvy's bladder cancer use, but Gilead is more hopeful of lung cancer success.

Gilead
• Source: Shutterstock

Gilead’s Trodelvy has racked up another failed Phase III study, this time falling short in a confirmatory TROPiCS-04 trial in metastatic urothelial carcinoma (mUC).

That is a setback for the TROP-2 directed antibody-drug conjugate in an increasingly competitive field, but it remains to be seen if the US Food and Drug Administration will demand...

Key Takeaways

  • Trodelvy’s two biggest indications are in triple breast cancer and HR+/HER2- breast cancer, but a market removal in bladder cancer would still be a blow...

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