1. Scrip
  2. >>Therapy Areas
  3. >>Immunological

Cartesian Looks To Chart The Way For CAR-T In Autoimmune Disease

 
• By Jessica Merrill

A Phase IIb trial testing Cartesian’s autologous mRNA-engineered CAR-T therapy for the treatment of generalized myasthenia gravis (MG) met the primary endpoint.

autoimmune disease
Cartesian announced clinical trial data for a CAR-T in autoimmune disease. • Source: Shutterstock

Cartesian Therapeutics, Inc. has positive data from a Phase IIb trial testing Descartes-08, an autologous mRNA-engineered chimeric antigen receptor T-cell (CAR-T) therapy directed against the B-cell maturation antigen (BCMA) in patients with generalized myasthenia gravis (MG), positioning the company at the forefront of development of CAR-T therapeutics for autoimmune disease.

Key Takeaways
  • A Phase IIb trial testing Descartes-08, an autologous mRNA-engineered CAR-T therapy in patients with generalized myasthenia gravis (MG), was positive.

The trial represents the first placebo-controlled study of a CAR-T cell therapy in autoimmune disease to the best of Cartesian’s...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required
Start Free Trial

Already a subscriber?

More from Immunological

More from Therapy Areas

GSK’s Blenrep US Setback Could Go From Bad To Worse

 
• By Sushmita Panda

With a US approval any time soon now looking unlikely, analysts are revising Blenrep’s peak sales guidance downwards.

Boehringer Ingelheim Expects Two Key Approvals In Second Half Of 2025

 
• By Andrew McConaghie

The privately held German pharma firm is hoping to bring a new generation of pulmonary fibrosis and cancer drugs to market but their commercial success is not yet a certainty.

More Pressure on Elevidys As The EU’s CHMP Says ‘No’

 
• By Alexandra Shimmings

Just days after Roche stopped shipments of the DMD gene therapy following safety concerns raised by two patient deaths, its EU approval application has hit a block.