In the top alliance by deal value, Orna Therapeutics (through its ReNAgade Therapeutics subsidiary) entered a three-year research collaboration with Vertex Pharmaceuticals designed to use Orna’s novel lipid nanoparticle delivery vehicles to improve Vertex’s efforts in developing next-generation, gene editing therapies for patients with sickle cell disease and transfusion-dependent Beta thalassemia.
Deals In Depth, January 2025
Ten $1bn+ alliances were penned in January, and two exceeded $2bn.

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Three $1bn+ alliances were penned in February, and one exceeded $2bn.
An interactive look at pharma, medtech and diagnostics deals made during February 2025. Data courtesy of Biomedtracker.
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