Artiva Leverages Unmodified NK Cells To Challenge CAR-T Paradigm

Artiva Biotherapeutics is hoping its NK cell therapy approach, which uses un-engineered cells, will prove effective in both oncologic and autoimmune indications and safe enough to be given in the community setting.

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Natural killer cell destroying a cancer cell (Shutterstock)
Key Takeaways
  • Artiva's lead candidate AlloNK, when combined with rituximab, has shown a 62% complete response rate in non-Hodgkin lymphoma patients and can be administered in an outpatient setting, unlike CAR-T therapies that require hospitalization.
  • The company's manufacturing process can generate over 4,000 treatment vials from a single umbilical cord at approximately $1,000 cost per vial, potentially making cell therapy more accessible than current CAR-T approaches.
  • Following promising academic results using CAR-T for lupus, Artiva is expanding into autoimmune diseases with clinical trials in SLE and lupus nephritis, leveraging NK cells' natural behavior and short persistence for "immune reset."

In the maturing landscape of cell therapy, Artiva Biotherapeutics stands out for its unique approach: using un-engineered natural killer

Under the leadership of Fred Aslan, the San Diego-based company hopes its approach will make cell therapy more accessible to

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