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Beyond CPAP: Apnimed’s Potential To Transform Sleep Apnea Management

 
• By David Wild

Boston-area biotech Apnimed expects Phase III readouts for its obstructive sleep apnea combination drug by May. Patients with OSA are desperate for a pill to treat the condition, and GLP-1 agonists are only part of the solution.

Apnimed's two Phase III trials of its obstructive sleep apnea candidate will read out mid-2025 (Shutterstock)
Key Takeaways
  • Apnimed's AD109, addressing the neuromuscular dysfunction component of obstructive sleep apnea (OSA), offers a complementary solution to GLP-1 therapies like Eli Lilly's Zepbound, potentially benefiting both obese and non-obese OSA patients.
  • With a significant reduction in Apnea-Hypopnea Index (AHI) and robust safety data, AD109's Phase II results have laid the groundwork for two Phase III trials expected to read out by mid-2025.
  • Backed by $208M in funding, Apnimed is building its commercial and medical affairs teams while gearing up for the US launch of AD109, positioning itself as a strong player in the evolving OSA treatment landscape.

Lawrence Miller is not afraid of giants. The CEO of sleep apnea-focused Apnimed believes that even though Eli Lilly’s Zepbound (tirzepatide) recently won approval for treating moderate-to-severe obstructive sleep apnea...

For one, some patients in Lilly’s SURMOUNT-OSA trials whose condition improved with Zepbound had residual OSA.

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