New EU Filings Include First-Of-Its-Kind MS Drug Tolebrutinib & HIV Prophylaxis Lenacapavir

Several new drugs that are yet to be approved anywhere in the world are now under review by the European Medicines Agency for potential pan-EU marketing authorization.

Neurodegenerative disease concept 3d illustration
Tolebrutinib is an oral, brain-penetrant and bioactive BTK inhibitor for treating multiple sclerosis (Shutterstock)
Key Takeaways
  • The European Medicines Agency has started reviewing the marketing authorization applications for eight new drugs – tolebrutinib, lenacapavir, levodopa/carbidopa, estetrol, aflibercept, teriparatide, and two midazolam products.
  • Lenacapavir, from Gilead Sciences, is a twice-yearly injectable HIV-1 capsid inhibitor for the prevention of HIV, which the EMA is fast tracking.
  • It is being by reviewed by the EMA in parallel with another marketing application for the product that Gilead has submitted under the EU-Medicines for all (EU-M4all) pathway, which is designed to facilitate the availability of medicines in low- and lower-middle-income countries.
  • Levodopa/carbidopa (ND0612) is Mitsubishi Tanabe Pharma’s investigational drug-device combination therapy – a 24 hours/day, continuous subcutaneous infusion of liquid levodopa/carbidopa – for the treatment of motor fluctuations in people with Parkinson's disease

Tolebrutinib, Sanofi’s investigational treatment for non-relapsing secondary progressive multiple sclerosis (nrSPMS), is among the latest products that the European Medicines Agency has started reviewing for potential pan-EU marketing approval.

The oral, brain-penetrant, and bioactive Bruton’s tyrosine kinase inhibitor is a first of its kind medicine for nrSPMS, according to Sanofi, which said there were no approved treatments available for...

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