Volastra Aims To Terminate Cancer Relying On Chromosomal Instability

Emerging Company Profile: Volastra is testing two KIF18A inhibitors in early clinical trials in ovarian cancer, backed by investors like Polaris Partners and ARCH Ventures.

A 3D illustration depicting Cancer Cells in the crosshairs, related to cancer treatment
Pharma firms are pursuing new ways of addressing known targets • Source: Shutterstock

Volastra Therapeutics has a goal to exploit chromosomal instability (CIN) – the process by which cancer cells divide and are able to evade the body’s normal responses – to develop a new category of cancer therapeutics. With venture capital support from big investors including Polaris Partners and ARCH Ventures, the New York City-based start-up has advanced two potential first-in-class drugs into clinical development within five years of its founding.

“What we’ve spent the last five years doing is really being a biology-focused company where we can understand chromosomal instability in a way that no one has tackled up until...

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