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Blow For Celgene As Revlimid Trial Miss Removes Blockbuster Indication

 
• By Lucie Ellis-Taitt

Celgene Corp.'s hopes of extending the market reach of its blockbuster oncology therapy Revlimid (lenalidomide) have taken a blow as Phase III data for the drug in elderly diffuse large B-cell lymphoma (DLBCL) patients have failed to show benefit on overall survival.

Dart board

The highly anticipated REMARC trial – which evaluated maintenance therapy with Revlimid compared with placebo in elderly DLBCL patients responding to first-line rituximab plus CHOP chemotherapy (R-CHOP) induction therapy – achieved its primary endpoint of a significant improvement in progression-free survival, but an interim analysis of overall survival data produced disappointing results for Celgene Corp. and its partner the Lymphoma Academic Research Organisation (LYSARC).

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Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.