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Fovista AMD Failure Puts Eylea In The Clear, Blurs Anti-PDGF Prospects

 
• By Sten Stovall

The failure of two Phase III Fovista and Lucentis combination trials in treating wet AMD probably lifts the threat of shifts towards PDGF/VEGF combinations and thereby leaves Regeneron's Eylea sales in the clear.

The failure of two Phase III trials combining Fovista (pegpleranib) with Lucentis (ranibizumab) will likely bring to an end the debate over whether efficacy of vascular endothelial growth factor (VEGF) inhibition in the treatment of wet age-related macular degeneration (AMD) can be enhanced by the simultaneous inhibition of platelet-derived growth factor (PDGF).

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Pipeline Watch: Ten Approvals And Eleven Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.