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With Phase III Failure, Cytokinetics Shelves Tirasemtiv, Pivots To ALS Backup

 
• By Joseph Haas

Partnered with Astellas, the San Francisco-area biotech hopes next-generation CK-107 will succeed in a measure of slow vital capacity due to stronger potency and better tolerability compared to tirasemtiv.

nerve cells, concept for neurodegenerative and neurological disease

Cytokinetics Inc. thought it had the answer in mid-2016 when it decided to design a Phase III in amyotrophic lateral sclerosis (ALS) around a secondary endpoint it hit in Phase II with tirasemtiv, but it didn't. The company reported Phase III results showing the novel skeletal muscle activator did not hit the primary or any secondary endpoints in the VITALITY-ALS study and now it is shelving the compound.

The San Francisco-area biotech revealed the Phase III failure Nov. 21, but added that it is not giving up on its mechanism of action in ALS

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