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Novartis' Late Bloomer Entresto Leads Take-Off Of Heart Failure Market

 
• By Emily Hayes

Market snapshot: Growth of Novartis' Entresto along with greater use of SGLT-2 inhibitors and the entry of new branded drugs will boost sales of drugs for chronic heart failure from $4.6bn in 2017 to $10.1bn in 2026, despite wide availability of generics, according to a new Datamonitor forecast.

Airliner in flight

Novartis AG's chronic heart failure drug Entresto was very slow to get off the ground, but now sales are building fast and improved performance will help fuel significant growth in the market in coming years, despite the wide availability of generics as the standard of care, according to a new report from Datamonitor Healthcare.

Entresto is a first-in-class combination of Novartis' angiotensin receptor blocker valsartan (Diovan and generics) and the neutral endopeptidase (NEP) inhibitor sacubitril. Approved in July 2015 for patients with chronic heart failure (CHF) and reduced ejection fraction (HFrEF), the drug appeared to have everything going for it – having proven a strong, significant reduction in a range of cardiovascular events in the PARADIGM-HF outcomes study. It also had a $4,500 annual launch price tag that was deemed to be cost-effective

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