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Is Imfinzi The Culprit As Advaxis Combo Trial Goes On Hold After Death?

 
• By Kevin Grogan

The FDA has placed a clinical hold on a Phase I/II trial for HPV-related cancers of Advaxis' axalimogene filolisbac in combination with Imfinzi after a patient died due to respiratory failure but analysts at Jefferies believe the fault could lie with AstraZeneca's PD-L1 inhibitor.

Road closed
At least for the moment: The FDA has stopped Advaxis' trial after patient death • Source: Shutterstock

Advaxis Inc. stock has taken a battering following the news that the FDA has placed a clinical hold on a Phase I/II trial of axalimogene filolisbac in combination with AstraZeneca PLC's PD-L1 inhibitor Imfinzi (durvalumab) to treat human papillomavirus (HPV)-related cancers after a patient death, although the US biotech does not believe its drug was the cause.

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