Vertex Targeting Protein Degradation In $1bn Kymera Deal

Vertex and Kymera will use insights into the ubiquitin-proteasome pathway, for sending unwanted proteins off to recycling, to discover new drug candidates.  

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A new therapeutic approach involves using the way cells tag unwanted proteins for recycling • Source: Shutterstock

New treatment modalities are rare in pharma R&D, but Vertex Pharmaceuticals Inc. has joined the buzz surrounding the development of novel medicines targeting protein degradation by linking up with Kymera Therapeutics Inc. to discover small-molecule protein degraders for use against multiple diseases.

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