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Dyno Therapeutics Emerges With Novartis, Sarepta Deals For Novel AAV Capsids

 
• By Mandy Jackson

Dyno raised $9m in 2018 but came out of stealth mode with deals worth up to $2bn based on its platform using high throughput biology, AI and machine learning to engineer next-generation AAV capsids.

Adeno-associated virus serotype 1. Virus is used as a vector for gene therapy
Dyno's novel AAV capsids could expand gene therapy's reach • Source: Shutterstock

The idea for Dyno Therapeutics Inc.’s CapsidMap platform for developing novel capsids for adeno-associated virus (AAV) vectors came to fruition after CEO and co-founder Eric Kelsic joined the Harvard University lab of George Church as a post-doc in 2015. The company officially launched in 2018 with $9m in seed funding and now it is emerging from stealth mode with gene therapy partnerships that Dyno says are worth up to $2bn in upfront payments, research funding and milestone fees.

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