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ESMO: Pfizer's Lorbrena Makes Case To Claim ALK+ Lung Cancer CROWN

But 'Unique Side Effects' A Concern

 
• By Kevin Grogan

Lorbrena is approved as a second-line treatment for ALK-positive NSCLC but Pfizer believes data from the first-line Phase III CROWN study makes the drug a serious competitor to standard of care Alecensa in the first-line setting.

Lung Cancer
Pfizer pushing in ALK-Positive lung cancer space • Source: Shutterstock

Pfizer Inc.'s Lorbrena has knocked the spots of the company's predecessor Xalkori for ALK-positive non-small cell lung cancer (NSCLC) in a Phase III trial, putting the drug in a position to challenge Roche Holding AG’s Alecensa, Novartis AG’s Zykadia and Takeda Pharmaceutical Co. Ltd.’s Alunbrig as a first-line treatment.

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