Two new entrants into the PI3 kinase (PI3K) inhibitor space presented at the American Society of Hematology annual meeting may help reinvigorate a class of drugs for indolent non-Hodgkin’s lymphomas (NHL) whose members have often had to contend with unfavorable toxicity profiles. The two drugs – TG Therapeutics, Inc.’ umbralisib and Incyte Corporation’s parsaclisib – have shown high response rates and significantly better safety and tolerability than two of the PI3K inhibitors on the market, Gilead Sciences, Inc.’ Zydelig (idelalisib) and Verastem, Inc.’s Copiktra (duvelisib).
Incyte, TG's PI3K Inhibitors Show Safety Advantage In Indolent NHL
Data At ASH Show Strong Efficacy, Favorable Safety For Umbralisib, Parsaclisib
Neither TG's UNITY-NHL nor Incyte's CITADEL-203 study reported any fatal adverse events - a problem for which Gilead and Verastem's PI3K inhibitors carry boxed warnings.
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