AstraZeneca PLC has had a disappointing few days with two novel products, with the topline failure of the Phase III SOURCE study of its asthma candidate tezepelumab coming on top of a US approval delay for the anemia in kidney disease therapy roxadustat, announced on 18 December. The UK company had better news, however, with the expanded US approval for Tagrisso (osimertinib) for early-stage EGFR mutant non-small cell lung cancer on the ADUARA study on 21 December.
AstraZeneca Sees SOURCE Tezepelumab Failure In Asthma
Comes After Delay For Roxadustat In The US
The SOURCE failure is a reversal for the novel Amgen-partnered TSLP inhibitor after NAVIGATOR success last month, and comes just days after the US FDA requested more analyses of the pivotal data for the kidney disease anemia therapy roxadustat.
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