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Amgen After ASCO: Questions Remain On Lumakras, Bemarituzumab

 
• By Mandy Jackson

Remaining questions after ASCO include whether Lumakras (sotorasib) might work in first-line NSCLC with certain co-mutations and if ocular toxicities will hamper bemarituzumab in gastric cancer.

Lung cancer; wooden puzzle on dark surface
Questions about Lumakras in KRAS G12C-mutated lung cancer with co-mutations may be answered in Phase III • Source: Alamy

Amgen, Inc. went into the American Society of Clinical Oncology (ASCO) meeting with a new US Food and Drug Administration approval for its closely watched, first-to-market KRAS G12C inhibitor Lumakras (sotorasib) in non-small cell lung cancer (NSCLC), and presented data during the meeting from a single-arm Phase II study that showed a 12.5-month overall survival rate that could be practice-changing in the second-line treatment of NSCLC.

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