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Takeda Sees Another Wave 1 Plan Come Crashing Down

 
• By Joseph Haas

The Phase III failure for pevonedistat in three rare blood cancer settings is the third setback for Takeda’s Wave 1 pipeline candidates this year. The NEDD8 inhibitor is still being studied in other settings.

Leukemia
Takeda's NEDD8 inhibitor failed a Phase III study in MDS and leukemia

Takeda Pharmaceutical Co. Ltd. still has plenty of shots on goal with its Wave 1 pipeline of new molecular entities and label expansion efforts, but the Phase III failure of pevonedistat in high-risk myelodysplastic syndromes or two types of leukemia is another setback for its hyped R&D reorganization strategy this year. The Japanese pharma announced on 1 September that the NEDD-8 activating enzyme inhibitor failed to meet a predefined measure of statistical significance for event-free survival in the Phase III PANTHER trial.

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