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Novartis's Big Hopes For Transplant Drug Blown Apart

Iscalimab Not Effective Enough In Preventing Kidney Rejection

 
• By Kevin Grogan

Long touted as one of the drugs to watch in the Swiss giant's pipeline, iscalimab's chances of replacing tacrolimus as the standard of care preventing organ rejection in transplant patients have been dealt a hefty blow after a Phase II trial failure.

transplant
Less than half of donated kidneys last 10 years • Source: Alamy

Novartis AG's efforts to develop a drug that could result in more durable organ transplants have been hobbled by mid-stage data showing that its investigational anti-CD40 targeting monoclonal antibody iscalimab was less effective in preventing kidney rejection than the standard of care.

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