AstraZeneca PLC’s Alexion unit has exercised an option to acquire the remaining equity in Caelum Biosciences, Inc. and get control of a promising late-stage candidate for the treatment of light chain (AL) amyloidosis, a rare, tough-to-treat protein misfolding disorder.
AstraZeneca Goes All In On AL Amyloidosis With Caelum Acquisition
Deal Could Be Worth Up To $500m
AstraZeneca’s recently-acquired Alexion unit is paying $150m upfront to buy the remainder of Caelum Biosciences and its late-stage therapy for light chain amyloidosis, a rare disease in which misfolded amyloid proteins build up in organs throughout the body, including the heart and kidneys.

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