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Novartis Debuts Rapidly Manufactured Autologous CAR-Ts

 
• By Alaric DeArment

The company presented early data on two candidates at the ASH meeting that use a less than two-day manufacturing process, YTB323 in diffuse large B-cell lymphoma and PHE885 in multiple myeloma.

3d illustration of T cells or cancer cells
Novartis unveiled early data on its two next-generation CAR-Ts, YTB323 and PHE885 • Source: Shutterstock

Although it was the first mover in getting a chimeric antigen receptor T-cell (CAR-T) therapy approved, Novartis AG has somewhat fallen behind its peers in terms of number of cell therapies on the market and number of indications. Next-generation cell therapies like CAR-NKs and allogeneic CAR-Ts are coming into play as well. But the Swiss drug maker is looking to make its mark with a new autologous cell therapy technology that speeds manufacturing, and introduced early data on two of these candidates at the American Society of Hematology (ASH) annual meeting.

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