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Subgroup Could Give Xpovio Focused Commercial Opportunity In Endometrial Cancer

 
• By Alaric DeArment

Karyopharm’s Phase III SIENDO study showed what analysts called a “modest” progression-free survival improvement overall, but a fourfold improvement in patients with wild-type p53.

Digital illustration of Cancer cell in colour background
Karyopharm announced topline results from its Phase III SIENDO trial in endometrial cancer • Source: Shutterstock

Although Karyopharm Therapeutics’s Phase III SIENDO trial of Xpovio (selinexor) technically achieved its primary endpoint with a statistically significant gain in median progression-free survival (PFS), the benefit was modest compared to the improvement among patients with wild-type p53, suggesting the drug could see its biggest commercial opportunity in the subgroup.

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