Morningside Ventures launched Adiso Therapeutics on 10 March with more than $60m invested to date in the Concord, MA-based start-up focusing on the underlying biology of inflammatory diseases without causing systemic immunosuppression. Adiso has two assets in clinical development for the prevention of C. difficile infection recurrence and treatment of ulcerative colitis as well as a discovery-stage effort in respiratory inflammation under way.
Finance Watch: Morningside Launches Adiso With More Than $60m In Early Funding
Start-Up Has Two Clinical-Stage Product Candidates
Private Company Edition: In addition to Adiso, Creyon recently launched with $40m and TRexBio extended its series A by $26m to $85m total. Also, Kurma Partners raised the first €160m of a planned €250m fund to back companies transitioning from R&D to commercial operations.

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Public Company Edition: Stock valuations are falling due to political, economic and regulatory uncertainty, resulting in fewer large public offerings, more alternative financings and cost cuts. Carisma, Tenaya, BioAtla, Arbutus, Nkarta, Alector and Adaptimmune announced layoffs.
CEO Kris Elverum told Scrip about the start-up’s platform for editing RNA to correct genetic variants that cause harm and to reproduce healthy variants as a means of treating disease.
The four-year-old firm said it plans to advance programs toward the clinic from the funding round, which comes just over a year after signing two major pharma partnerships.
Private Company Edition: The latest group of drug developers to announce venture capital financings is remarkable for its geographic diversity, from Character Biosciences’ $93m series B round in the US to Augustine’s $85m series B in Belgium to a $29.2m series C for Aculys in Japan.
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