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Roche’s Vabysmo Chases Regeneron’s Eylea With New Pivotal Macular Edema Wins

 
• By Ayisha Sharma

The Swiss major’s new bispecific antibody could challenge Eylea’s standard of care status in another ophthalmic indication, macular edema due to retinal vein occlusion, but the older rival is set to hit back in bigger markets with a high-dose reformulation.  

Hand breaking through the wall
Vabysmo Could Soon Break Into New Macular Edema Settings • Source: Shutterstock

Roche Holding AG’s Vabysmo (faricimab) is chasing Bayer AG/Regeneron Pharmaceuticals, Inc.’s Eylea’s tail in two further macular edema indications, new topline Phase III data show, but the older product could win back market share in more significant indications with a high-dose reformulation.

Vabysmo met the primary endpoint of non-inferior visual acuity gains when compared with Eylea (aflibercept) in hundreds of patients with macular edema due to branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) in the BALATON and

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