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A Strong Start For Amvuttra, But Alnylam Bides Time On Heart Results And US Price Control Plans

Company Will Await Full Readout In 2024

 
• By Andrew McConaghie

Alnylam has scrapped plans for an interim analysis of its all-important HELIOS-B study of its new ATTR therapy, hoping that a 2024 readout will be more compelling, while the US Inflation Reduction Act has put the brakes on development in another indication.

Alnylam building
Alnylam's HELIOS-B study is expected to read out in early 2024, allowing it to take on Pfizer's Vyndaqel and Vyndamax. • Source: Alamy

Alnylam’s new second-generation RNAi product, Amvuttra, has got off to a strong start, achieving a 30% growth in third-quarter US sales compared with the previous three months, but the company has put off a peek at data from a crucial trial in a larger potential patient population.

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