Astellas Pharma, Inc.'s key oncology candidate zolbetuximab has met its primary and secondary endpoints in the Phase III SPOTLIGHT trial in combination with chemotherapy for gastrointestinal cancers, paving the way for a possible approval filing for the first-in-class, claudin (CLDN) 18.2-targeting antibody.
Astellas's First-In-Class CLDN18 Antibody Meets Phase III Gastric Endpoints
Competitive Advantage Vs Opdivo?
Novel candidate acquired from Ganymed in 2016 moves closer to first approval filing anywhere for a CLDN18-targeting antibody, and as a potential competitor for Opdivo in HER2-negative gastric cancer, following positive top-line Phase III results in the first-line combo setting. Results from GLOW trial in combination with CAPOX also awaited.
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