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Duchenne Doldrums Continue As Entrada Hit With IND Clinical Hold

 
• By Ayisha Sharma

The US firm’s lead oligonucleotide asset, ENTR-601-44, has received a clinical hold notice after IND submission, adding to a growing list of companies in the Duchenne space facing setbacks.  

Dystrophin, skeletal muscle cell
Dystrophin Is One Of A Family Of Proteins That Protects Muscle Cells • Source: Shutterstock

Entrada Therapeutics, Inc.’s investigational new drug application for lead program ENTR-601-44 for Duchenne muscular dystrophy (DMD) has been hit with a clinical hold notice from the US Food and Drug Administration, reflecting broader regulatory caution in the disease that has affected several firms.

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