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Aptinyx Pulls Back From Neuropsychiatry After Mid-Stage PD Failure

Prioritizes Cutting Costs

 
• By Ayisha Sharma

The US firm has faced yet another clinical setback as its Phase II candidate, NYX-458, failed to improve cognitive impairment in patients with Parkinson’s disease and Alzheimer’s, triggering the cessation of its only other program as priorities shift to preserving funds.    

Business man in suit looking at a red arrow pointing downwards, crashing through the ground in front of him
The Parkinson's Failure Is The Fourth Clinical Setback In Recent Years • Source: Shutterstock

Aptinyx, Inc.’s future is looking increasingly uncertain after it experienced yet another clinical trial failure. Its hopes in the neuropsychiatry space have died following a Phase II flop in Parkinson’s disease (PD) and dementia, prompting the firm to wind down clinical activities for a separate post-traumatic stress disorder (PTSD) asset and focus on cutting costs amid a dwindling cash runway.

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