AstraZeneca PLC and Ionis Pharmaceuticals, Inc. hope to bring a best-in-class treatment for hereditary transthyretin-mediated amyloidosis (ATTR) to market, starting with ATTR polyneuropathy (ATTRv-PN), and have delivered longer-term results for eplontersen that could make their drug a strong competitor to Alnylam Pharmaceuticals Inc.’s Amvuttra (vutrisiran).
AstraZeneca/Ionis’s Eplontersen Shows Competitive Efficacy In ATTR Polyneuropathy At 66 Weeks
US FDA Approval Pending With Decision Due In December
Patients continued to improve across all three Phase III NEURO-TTRansform co-primary endpoints with 29 more weeks of treatment, setting up eplontersen to challenge Alnylam’s Amvuttra.
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Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.
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