Drug development in hematology-oncology can sometimes happen at such a fast, paradigm-busting pace that the selection of treatments even 20 years ago can look like prehistory compared to what is available now. Few indications exemplify such rapid change more than multiple myeloma – where small molecule drugs that have long served as backbone treatments are going generic, new biologics with novel targets have rapidly become backbone treatments themselves, and other drugs with new mechanisms have struggled to gain widespread acceptance.
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