One of the initial reactions to news that the US Food and Drug Administration is investing reports of T-cell malignancies in patients treated with approved CD19- and BCMA-targeting chimeric antigen receptor T-cell (CAR-T) therapies for hematological malignancies was that CAR-T candidates being developed for autoimmune diseases could be derailed by the potential safety risk. However, many patients with autoimmune diseases and cancer already accept some risk of secondary malignancy.
Risk/Benefit Of CAR-T For Autoimmune Diseases May Shift With FDA Investigation
Use Could Be Restricted To Most Severe Patients
CAR-T therapy-associated T-cell malignancies that the US FDA is investigating could make the treatments less attractive in autoimmune diseases than in oncology, but patients in both settings already accept some cancer risk with other available medicines.
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