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Do The Dark Clouds Over Gilead’s Trodelvy Have A Silver Lining?

 
• By Alaric DeArment

Despite a primary endpoint miss in previously treated NSCLC in EVOKE-01, analysts say the drug still has points of differentiation from the competition. 

Gilead announced results from the EVOKE-01 study of Trodelvy • Source: Shutterstock

A key late-stage clinical trial of Gilead Sciences, Inc.’s Trodelvy (sacituzumab govitecan-hziy) failed, causing the company’s stock to drop and raising questions among analysts about its position relative to its competitor, AstraZeneca PLC/Daiichi Sankyo Co., Ltd.’s datopotamab deruxtecan (dato-DXd). But the results were not seen as entirely negative, given that EVOKE-01 was in a difficult population where dato-DXd has also seen lackluster results.

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