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Sagimet Plans Move To Phase III In NASH By Year-End

 
• By Joseph Haas

Sagimet reported positive Phase IIb data for denifanstat in non-alcoholic steatohepatitis that may place the once-daily, oral drug as a serious competitor in a disease that at present has no approved drug therapy.

Fatty liver
Sagimet is looking to take its NASH candidate into Phase III later this year • Source: Shutterstock

Sagimet Biosciences hopes to bring its fatty acid synthase (FASN) inhibitor denifanstat into Phase III development for non-alcoholic steatohepatitis (NASH) during the second half of 2024 after a Phase IIb trial showed the drug can reduce disease activity and fibrosis.

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