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Takeda’s Soticlestat Fails In Seizure Trials

 
• By Jessica Merrill

Two Phase III studies testing soticlestat, licensed from Ovid, in Dravet and Lennox-Gastaut syndromes failed to meet their primary endpoints on improvement in seizure frequency.

Missed target
Two of Takeda's Phase III studies missed the primary endpoint • Source: Shutterstock

Takeda Pharmaceutical Co. Ltd.’s late-stage candidate soticlestat (TAK-975) failed in two Phase III clinical trials for convulsive seizures, a setback in what is already poised to be a challenging year for the Japanese pharma.

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