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Vaxcyte Confident Of Pneumococcal Vaccine Dominance After Phase I/II Results

Phase III Adult Trials To Begin In 2025

 
• By Mandy Jackson

The company’s VAX-31 against 31 pneumococcal serotypes outperformed Pfizer’s market-leading Prevnar 20 and could provide the broadest coverage of any vaccine in its class.

Pneumococcal vaccine in a vial, immunization and treatment of infection, vaccine used for disease prevention
Vaxcyte will initiate adult and infant trials for VAX-31 in 2025 • Source: Shutterstock

Vaxcyte, Inc. reported Phase I/II clinical trial results in adults on 3 September for VAX-31, its pneumococcal conjugate vaccine (PCV) against 31 serotypes of Streptococcus pneumoniae, that would offer the broadest protection against pneumococcal disease, if eventually approved. The data met immunogenicity requirements needed for approval across all serotypes and achieved non-inferiority or superiority compared to Pfizer Inc.’s market-leading product Prevar 20 across all of the vaccines’ shared serotypes.

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